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March 4, 2011 - FDA Drug Safety Communication: TOPAMAX® (topiramate) use during pregnancy can cause fetal harm, including an increased risk for cleft lip and/or cleft palate. For information from the company click here. The FDA announcement can be found at www.fda.gov.

About TOPAMAX®

Are you tired of treating one migraine at a time?

If you think it's time to try another approach, talk to your doctor about TOPAMAX®.

TOPAMAX® can help stop migraines before they start so you can get fewer of them to think about.

How TOPAMAX® works

"Some migraine medications you take when you feel migraine pain coming on ...TOPAMAX® works differently. — it is a daily medication."

Some migraine medications are taken at the start of a migraine. They work one migraine at a time. TOPAMAX® works differently. It's a daily prescription medication that you take for as long as you and your healthcare professional decide you need it. Migraines may not be completely eliminated, but TOPAMAX® can help stop them before they start, so you can get fewer of them to think about.

Calming nerve cells in the brain

TOPAMAX® is believed to help "calm" the process that leads to migraines. During a migraine, overexcitable nerve cells send pain signals. With TOPAMAX®, it's believed that overexcitable nerve cells are "calmed" to help reduce migraine occurrence.

Is TOPAMAX® Right For Me?

TOPAMAX® significantly reduces migraine frequency

If your constant migraines are interfering with your life, it may be time to consider a daily preventive migraine treatment like TOPAMAX®.

Talking to your doctor about the impact of migraines on your life could be the next step to getting the treatment you need.

TOPAMAX® is the #1 prescribed medication for migraine prevention in the U.S. and it is proven to significantly reduce migraine frequency.

The studies of TOPAMAX® are large, well-controlled clinical trials conducted for migraine prevention, involving over 1,700 adult patients.

Dosage & Drug Interaction

Dosing With TOPAMAX®

The rule with TOPAMAX® is to "start low and go slow." That is, your healthcare professional will adjust your medication. You'll start with a low dose and then slowly increase the amount of TOPAMAX® you take until you reach the dosage that works best for you. Like many other medications, TOPAMAX® needs time to build up to the right level in your bloodstream before it is completely effective, so remember to be patient.

Your healthcare professional will determine your starting dose and when to make adjustments to your dose.

Be patient. TOPAMAX® can take time to work.

Although you'll be taking TOPAMAX® every day, it may take some time to work. In clinical studies, TOPAMAX® was proven to help reduce the frequency of migraines. Some patients experienced fewer migraines after 1 month of treatment; however, it may take 2 to 3 months to realize the full benefit of TOPAMAX®. That's why it's so important to continue to take your medication every day to give it the best chance to work.

What if I miss a dose?

If you miss a single dose of TOPAMAX®, take it as soon as you can. However, if you are within 6 hours of taking your next scheduled dose, wait until then to take your usual dose of TOPAMAX®, and skip the missed dose. Do not double your dose. If you have missed more than one dose, you should call your healthcare professional for advice.

TOPAMAX® Dosing Details:

TOPAMAX® can be taken with or without food.

Drug interaction

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. TOPAMAX® and other medicines may affect each other causing side effects. Especially tell your healthcare provider if you take:

  • Valproic acid (such as DEPAKENE or DEPAKOTE)
  • any medicines that impair or decrease your thinking, concentration, or muscle coordination
  • birth control pills. TOPAMAX® may make your birth control pills less effective.

Tell your healthcare provider if your menstrual bleeding changes while you are taking birth control pills and TOPAMAX®. Ask your healthcare provider if you are not sure if your medicine is listed above. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine. Do not start a new medicine without talking with your healthcare provider.